This chronology presents one hundred years of air and space flight and documents the evolution of U.S. aviation from the Wright brothers’ first powered flight at Kitty Hawk in 1903 to the sophisticated space and missile operations of the early 2000s. Detailed entries include early military flights at Fort Myer in Virginia, the establishment of key training centers at Langley Field and Maxwell Air Force Base, and records of pioneering achievements by officers such as Capt. Thomas E. Selfridge, General Henry H. Arnold, and Capt. Charles E. Yeager, whose supersonic flight tests at Muroc Air Base redefined performance. The timeline also captures critical advances in bomber development with aircraft like the B-52 operating from Vandenberg Air Force Base and highlights major strategic missions including the Berlin airlift from Andrews Air Force Base, the Apollo lunar missions launched from Cape Canaveral, and the deployment of intercontinental ballistic missiles that transformed global air power projection. Furthermore, it chronicles key humanitarian airlift operations, space reconnaissance achievements with the U-2 and SR-71, and the transformational reorganization that led to an independent U.S. Air Force and the integration of space operations.